The original College of Commerce and Finance was founded in 1922 by the Rev. Joseph C. Bartley, OSA, who served as dean until his death in 1962. Since that time, the school underwent many changes to meet the needs of the ever-changing business community, but it has continued to attract outstanding undergraduate and graduate students from across the nation and the world. In 2006, the school was renamed the Villanova School of Business (VSB).

Today it offers the Bachelor of Business Administration degree with majors in Accounting, Economics, Finance, Management, Management Information Systems, Marketing, and Real Estate. Co-majors in Business Analytic and International Business are also available and must be taken in conjunction with another business major. In addition, the Bachelor of Business Administration, Honors degree is also available for qualified students. Graduate programs include the Executive MBA, Professional MBA, Master of Accounting with Data Analytics, Master of Business Taxation with Data Analytics, Master of Science in Business Analytics, Master of Science in Church Management, and Master of Science in Finance.

The undergraduate and graduate business programs of VSB are fully accredited by the Association to Advance Collegiate Schools of Business (AACSB International). In addition, the accounting program is separately accredited by AACSB making it among a select number of accounting programs so designated.

VSB faculty include more than 118 full-time professors, with about 86% holding the terminal degree in their area of expertise. The faculty is widely recognized for its excellence in teaching, research and professional service, and adjunct professors are experts drawn from industry.

The School is also home to prestigious business research centers including the Center for Business Analytics, the Center for Church Management, the Daniel M. DiLella Center for Real Estate, the Elenore and Robert F. Moran Sr. Center for Global Leadership, and the Center for Marketing and Consumer Insights.